The two remaining members of tennis's big three will know that whoever reaches this year's final will be an overwhelming favourite given the Mallorcan's battler's shock demise under the Centre Court lights on Thursday.
"It is only a tennis match," was Nadal's philosophical take on being jettisoned in the tournament's second round.
"You win, you lose. Last four months were great for me....
"You arrive here, and a little bit of everything. You play against an inspired opponent and I am out. That's all. It is not a tragedy."
Djokovic, who faces 28th seeded Czech Radek Stepanek, and Federer, who takes on France's Julien Benneteau, have both looked in imperious form and not dropped a set in their opening two matches.
In the women's draw, world number one Maria Sharapova is back in action after returning on Thursday to finish off Tsvetana Pironkova, and plays Taiwan's Hsieh Su-wei on Court One in her third round clash.
Centre Court 1:00 PM Start Time
Novak Djokovic (SRB)[1] v Radek Stepanek (CZE)[28]
Agnieszka Radwanska (POL)[3] v Heather Watson (GBR)
Roger Federer (SUI)[3] v Julien Benneteau (FRA)[29]
No. 1 Court 1:00 PM Start Time
Sam Querrey (USA) v Milos Raonic (CAN)[21] To Finish 6-7(3) 7-6(7) 3-3
Maria Sharapova (RUS)[1] v Su-Wei Hsieh (TPE)
Vera Zvonareva (RUS)[12] v Kim Clijsters (BEL)
Nicolas Almagro (ESP)[12] v Richard Gasquet (FRA)[18]
No. 2 Court 11:30 AM Start Time
Viktor Troicki (SRB) v Juan Monaco (ARG)[15]
Christina McHale (USA)[28] v Angelique Kerber (GER)[8]
Mikhail Youzhny (RUS)[26] v Janko Tipsarevic (SRB)[8]
No. 3 Court 11:30 AM Start Time
Sloane Stephens (USA) v Sabine Lisicki (GER)[15]
Fernando Verdasco (ESP)[17] v Xavier Malisse (BEL)
Nadia Petrova (RUS)[20] v Camila Giorgi (ITA)
Court 12 11:30 AM Start Time
Women's doubles match
Anabel Medina Garrigues (ESP)[26] v Jana Cepelova (SVK) To Finish 7-6(7) 6-7(5)
Shuai Peng (CHN)[30] v Arantxa Rus (NED)
Florian Mayer (GER)[31] v Jerzy Janowicz (POL)
Court 18 11:30 AM Start Time
Women's doubles match
Alejandro Falla (COL) v Denis Istomin (UZB)
Sorana Cirstea (ROU) v Maria Kirilenko (RUS)[17]

Eurosport












