Monye has suffered a few injuries since last appearing for the Red Rose against Scotland in the 2010 Six Nations, when he was knocked out at Murrayfield on his 13th cap.
However he refuses the notion that his international career has been hampered by the physical problems.
"There's been injuries but [to say that they have hampered my international career] would be sugar-coating things," he told Eurosport.
"There's also been lack of form and confidence and on top of that there's been other players doing really well.
"Even now there's loads of big guys who could potentially fill your shoes and do a good job: David Strettle, Christian Wade, Jonny May, Matt Banahan."
After failing to make Martin Johnson's 2011 World Cup squad despite being in the pre-tournament training squad, he helped Quins to a maiden Premiership crown, prompting another recall.
However a head injury in a tour game against the South African Barbarians put paid to his chances of a Test appearance.
"After winning the Premiership I was on a high and looking forward to South Africa but that was down to injury, there was nothing I could do about that," he said.
"When you watch the boys you just want to be out there - it's very frustrating. That's why you play: you just want to be on the pitch. You don't want to be a guy who trains Monday to Friday and doesn't get the reward of playing on the Saturday.
"It's been hard at times but I've always had the belief that I'm good enough to get there. It's always special to play at Twickenham - when you've had a taste of something you are hungry to experience it again, especially after a couple of years."
Devout Christian Monye has been included in the starting XV and will finally run out again in the white of England again.
"It's been a couple of years since I got my last cap. That was a good period then but I'm glad to be back in the mix now and I think it's fully deserved as well as I've been playing well for Harlequins.
"I still feel I've got a lot to achieve with England if I can stay injury-free and hopefully will be given that opportunity."
He has been impressed by Stuart Lancaster's set-up.
"There aren't too many differences [with Johnson] but every coach has their own philosophies and knows the way they want to approach the game," he said.
"It's nice that Stuart looks at the players who are playing well for their clubs and tries to bring that on to the international stage. He's an easy guy to work with and he's certainly clear in what he wants - and his standards are very, very high."
Ugo Monye was speaking at the launch of O2 Inside Line, the weekly behind the scenes show from inside the England camp. For the latest episode and to receive email alerts for each show, visit www.O2InsideLine.com