France captain Thierry Dusautoir and winger Sofiane Guitoune have both been ruled out of the Six Nations.
France discarded Frederic Michalak and called up uncapped Jules Plisson in a 30-man preliminary squad for the Six Nations.
France claimed a hard-earned 23-16 victory over Scotland in Paris but still ended up with their first Six Nations wooden spoon on points difference.
Philippe Saint-Andre stuck with No.10 Frederic Michalak as France look to avoid the Six Nations wooden spoon against Scotland.
Manu Tuilagi, Courtney Lawes and Dylan Hartley will all start for England against France in the Six Nations on Saturday.
Vincent Clerc is back in the France squad for their Six Nations trip to England as Philippe Saint-Andre made five changes.
France captain Pascal Pape has been ruled out of the Six Nations game against Wales but the squad is otherwise unchanged.
Wing Vincent Clerc has been dropped from France's squad to face Italy in the Six Nations because of a thigh injury.
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