Stade Francais fly-half Jules Plisson will make his France debut in Saturday's Six Nations clash against England.
France captain Thierry Dusautoir and winger Sofiane Guitoune have both been ruled out of the Six Nations.
Round-up: Clermont and Munster both secured bonus-point wins on Sunday to earn home ties in the Heineken Cup quarter-finals.
Saracens saw their hopes of topping Pool Three all but ended in south-west France as they were beaten 21-11 by Toulouse.
France discarded Frederic Michalak and called up uncapped Jules Plisson in a 30-man preliminary squad for the Six Nations.
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