Worcester's Jeremy Su'a scored after 19 seconds but that still was not enough for the Warriors as they fell 33-25 to Biarritz.
Worcester's hopes of progressing in the Challenge Cup are effectively over, prompting director of rugby Dean Ryan to use the trip to Biarritz to experiment.
Jamie Heaslip will captain Ireland against Samoa on Saturday - but Paul O'Connell will be new coach Joe Schmidt's full-time skipper.
France manager Philippe Saint-Andre took a gamble on Thursday when he picked the inexperienced flyhalf Remi Tales.
Argentina lock Manuel Carizza will join Western Province in South Africa after his country's tour of Europe.
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