France scrumhalf Morgan Parra has been ruled out of next week's Six Nations clash in Scotland.
France coach Philippe Saint-Andre has dropped number eight Louis Picamoles from his squad to face Scotland next weekend.
Grenoble stunned Top 14 leaders Clermont 16-13 at the Stade Lesdiguières to move up to fourth in the French championship.
Clermont missed a chance to go top of the Top 14 as they fell to their sixth defeat of the season against Bayonne.
France captain Thierry Dusautoir and winger Sofiane Guitoune have both been ruled out of the Six Nations.
Wales prop Gethin Jenkins has rallied Cardiff Blues for an "all or nothing" mission against Heineken Cup holders Toulon on Saturday.
France discarded Frederic Michalak and called up uncapped Jules Plisson in a 30-man preliminary squad for the Six Nations.
Clermont Auvergne tightened their grip on Pool Four after completing a quickfire double against the Scarlets.
Morgan Parra is set to miss the Six Nations opener against England after being ruled out for 10 to 12 weeks.
At the end of a miserable year and just over two months before their Six Nations opener against England, France know exactly where they stand among the world's
South Africa failed to fire but they claimed their third win of the autumn internationals series with a 19-10 win over France.
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