The majority of the party featured in the Springboks worst ever Tri Nations campaign earlier this season but there are plenty of fresh faces for the two-day training camp the party will undertake in Johannesburg from Friday.
Elton Jantjies, Patrick Lambie, Lwazi Mvovo, Willem Alberts, Dean Greyley, Ashley Johnson, Werner Kruger, Gerhard Mostert, Coenie Oosthuizen, Duane Vermeulen and Deon Stegmann are the uncapped men, with Lions fly-half Jantjies and Sharks back Lambie having attracted particular attention for their excellent displays during the ongoing Currie Cup tournament.
The Springboks will be without captain John Smit when they head for the Northern Hemisphere because of injury while props Gurthro Steenkamp, hooker Gary Botha, centre Jaque Fourie, scrum-half Fourie du Preez, lock Andries Bekker and flanker Heinrich Brussow will also be missing.
De Villiers' final squad for the tour is set to be named on October 30 following the Currie Cup final.
South Africa's preliminary training squad for end-of-year tour of Britain and Ireland:
Backs: Gio Aplon, Bjorn Basson, Juan de Jongh, Jean de Villiers, Bryan Habana, Francois Hougaard, Adrian Jacobs, Elton Jantjies, Ricky Januarie, Zane Kirchner, Patrick Lambie, Lwazi Mvovo, Wynand Olivier, JP Pietersen, Morne Steyn.
Forwards: Willem Alberts, Bakkies Botha, Schalk Burger, Bismarck du Plessis, Jannie du Plessis, Dean Greyling, Alistair Hargreaves, Ashley Johnson, Ryan Kankowski, Werner Kruger, Victor Matfield, Gerhard Mostert, Tendai Mtawarira, Coenie Oosthuizen, Dewald Potgieter, Chiliboy Ralepelle, Danie Rossouw, Juan Smith, Adriaan Strauss, Pierre Spies, Deon Stegman, CJ van der Linde, Flip van der Merwe, Duane Vermeulen.