The Briton, fastest throughout, set two laps good enough for pole position as he underlined his control of proceedings by dipping into the 1m20s on his final Q3 lap.
That was easily enough to earn him a third pole of the year, with Lotus' Romain Grosjean - setting his fastest time at the flag - more than four tenths down in second.
Red Bull's Sebastian Vettel threatened to disrupt Hamilton's momentum late on in Q3, only to lose time in the final sector. He will nevertheless start from third, alongside Jenson Button in the second McLaren.
Senna just snuck into the final session, eliminating the second Red Bull of Mark Webber in the process.
Webber was left vulnerable when he failed to improve on his final Q2 lap, leaving him ninth with one minute of the session to run. That became 10th when Force India's Nico Hulkenberg came round, before Bruno Senna consigned Webber to an early exit as the flag fell.
Mercedes also endured a torrid qualifying, failing to break into Q3 with either car for the first time in 2012. Michael Schumacher couldn't recover from several wild moments and will start from 17th, with Nico Rosberg four places ahead of him in 13th.
The latter had sparked a mad Q1 scramble when he switched onto soft rubber and jumped up to fourth, forcing most of the field to follow suit.
As the laps played out Red Bull appeared to be in trouble but the team was ultimately able to tell both drivers to ease off as the scrap for the final Q2 place boiled down to Kobayashi and the second Toro Rosso of Daniel Ricciardo - the Australian eventually losing out.
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