Hoffenheim won 3-1 in the first leg of their relegation play-off with Kaiserslautern on Thursday night.
Bayer Leverkusen made sure of a place in next season's Champions League group stage with a 2-0 win at Nuremberg on Saturday.
Hoffenheim gave their Bundesliga survival hopes a boost with a 3-0 win over fellow strugglers Fortuna Dusseldorf.
Champions Borussia Dortmund beat Hoffenheim 3-1 on Sunday to move back into the Bundesliga top three.
Sven Schipplock scored in injury time as second-placed Schalke 04 slipped up in the Bundesliga title race with a 3-2 defeat at Hoffenheim.
Hoffenheim have been hit by a double injury blow to strikers Srdjan Lakic and Sven Schipplock.
Stuttgart's problems continued after a 1-0 home defeat by Freiburg left the 2006-07 champions firmly in a Bundesliga relegation battle.
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