The Italy international is under contract with the Serie A giants until June 2014 and is also a reported target of Roma.
Santon has taken a flight to England and will undergo a medical on Tuesday.
"At this time there is no possibility that Santon can join Roma because right now the aim is Newcastle," said Santon's agent Claudio Vigorelli to Corriere dello Sport.
The 20-year-old has been with Inter since 2008 and made 16 appearances in all competitions during the first half of last season.
He then went on loan in the second half of the campaign and made 11 league appearances for Cesena.