Redknapp, axed by Spurs in June, was appointed QPR manager in place of Mark Hughes last week but Defoe said he would not be tempted by a move across London to join a side who are bottom of the Premier League and without a win.
"That's not going to happen. I'm not leaving Tottenham, I love the club and to score goals at a big club like this is fantastic," Defoe told Sky Sports News.
"If the opportunity comes to leave the club it won't be happening. I don't want to leave, I'm a Spurs player - and I'm happy.
"I'd like to finish my career at Tottenham. I want to achieve something special here - it's a great time to be at the club."
Defoe has hit 10 goals in all competitions this season and backed Portuguese manager Andre Villas-Boas, who spent nine months in charge of Chelsea before being sacked in March, to win over wavering fans at White Hart Lane.
"It's difficult for any manager - when you come in you've got different ideas," said Defoe.
"It wasn't the best at Chelsea but that happens. It's part of life and being a manager but he's a fantastic manager and been fantastic for me.
"There's always a different approach each game and he's such a nice guy. All the lads want to fight and win for him. I'm just enjoying the journey and I'm sure he is as well," added Defoe.