Fiorentina striker Mario Gomez will return to Germany on Monday ahead of a medical check-up on his fitness.
Miroslav Klose has been ruled out of Germany's friendlies against Italy and England while Per Mertesacker will also miss the game in Milan.
Germany's hopes of ending an 18-year wait for international success hinge on the sealing of a porous defence.
Fiorentina medical staff claim Mario Gomez will be fully recovered “in around three weeks” despite reports of problems.
Germany may be missing more than half a dozen key players through injuries, including their top strikers, but anything other than automatic World Cup
Joachim Loew once again overlooked last season's Bundesliga top scorer Stefan Kiessling for their World Cup qualifiers.
Fiorentina earned a hugely impressive 2-1 victory away to Dnipro thanks to Massimo Ambrosini’s header.
Bayer Leverkusen needed a last-gasp stunner from substitute Jens Hegeler to beat Real Sociedad 2-1 in the Champions League.
Out-of-favour Germany forward Stefan Kiessling could earn a surprise recall to the national team for the first time since 2010.
Arkadiusz Milik's 88th-minute equaliser earned Augsburg a deserved 2-2 draw against Borussia Moenchengladbach.
Germany forward Miroslav Klose could miss the World Cup qualifiers against Ireland and Sweden next month after foot surgery.
New AS Roma coach Rudi Garcia has a chance to succeed where his three predecessors all failed by beating Lazio in the derby.
Mario Gomez will travel to Germany to see a specialist and undergo physiotherapy for his knee injury, reports suggest.
Fiorentina will be without playmaker David Pizarro for two Serie A games following his dismissal against Cagliari.
Fiorentina conceded a late goal, saw Mario Gomez get injured and lost their 100 per cent Serie A record in a 1-1 draw at home to Cagliari.
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