Samuel Umtiti starts at left-back for an otherwise full-strength Barcelona against a strikerless Sevilla.
Barca coach Luis Enrique makes four changes from the 4-1 win at Granada on Sunday with Messi joining Luis Suarez and Neymar in attack after a one-match suspension.
Jordi Alba drops to the bench with Jeremy Mathieu omitted from the squad to make way for Pique's return, who was rested at the weekend.
Sergi Roberto, Sergio Busquets, Ivan Rakitic and Andres Iniesta form a four-man midfield.
Barcelona can go one point clear of leaders Real Madrid with a win before Zinedine Zidane's side visit Leganes at 8:30pm (BST).
Barcelona: Ter Stegen; Sergi, Pique, Mascherano, Umtiti; Rakitic, Busquets, Iniesta; Messi, Suarez, Neymar..subs: Cillessen, Denis, Alcacer, Alba, Digne, Gomes, Alena
Sevilla: Sergio Rico; Mercado, Pareja, Lenglet; Mariano, Iborra, N'Zonzi, Correa, Escudero; Nasri; Vitolo..subs: Kranevitter, Carrico, Ben Yedder, Soria, Jovetic, Sarabia, Vazquez