Powell made six changes to his side as they were beaten 3-0 by Brentford in the Johnstone's Paint Trophy on Wednesday night.
Ben Hamer will return in goal while Chris Solly, Michael Morrison and Rhoys Wiggins come back in defence.
Midfielder Bradley Pritchard is still on the sidelines with a foot injury and defender Leon Cort is on international duty with Guyana.
Tranmere captain John Welsh will have to sit the game due to a one-match suspension.
The midfielder missed Rovers' Johnstone's Paint Trophy game with Accrington, but as the game was abandoned, the ban carries over when they travel to The Valley.
Manager Les Parry told the club's official website: "John can't play against Charlton which is ridiculous. I'd have thought the sensible thing to do in the circumstances would be that he can't play the next time we play against Accrington."
Striker Adam McGurk will have a late fitness test on the groin injury which kept him out of the game with Stanley.
Parry has also confirmed that Martin Devaney and Andy Robinson (both hamstring) are still sidelined.