Striker Emmanuel Gigliotti gave Boca Juniors a 1-0 win over Estudiantes.
Argentina coach Alejandro Sabella has picked defenders Lisandro Lopez, Gino Peruzzi and Nicolas Otamendi for a World Cup warm-up.
Boca Juniors duo Fernando Gago and Agustin Orion and Newell's Old Boys' Maxi Rodriguez and Ever Banega have more than the Argentine league title to play for.
Ever Banega has joined Newell's Old Boys on loan from Valencia for the rest of the season.
We profile South American giants Argentina as Lionel Messi aims to emulate 1986 World Cup hero Diego Maradona.
Boca Juniors all but blew their chances of winning Argentina's league championship on Sunday when they were upset 2-0 by troubled All Boys at La Bombonera.
Uruguay may have reached the last four at the 2010 World Cup, but they will be under no illusion when they seek an unlikely high-scoring triumph over Argentina.
Angel Di Maria and Sergio Aguero will miss Argentina's final South American World Cup qualifer against Uruguay.
Newell's Old Boys beat River Plate 1-0 in Rosario on Sunday to stay three points clear at the top of the Argentine Inicial championship.
Striker Ezequiel Lavezzi scored two first half goals as Argentina beat Peru 3-1 in a World Cup qualifier.
Lionel Messi's injury absence is a psychological blow to Argentina and requires a solution so rivals cannot take advantage.
Fernando Gago was absent from Argentina coach Alejandro Sabella's revised squad for their last two World Cup qualifiers.
The spectre of hooligan violence has overshadowed the build-up to the "Superclasico", when River Plate host Boca Juniors.
Gonzalo Higuain and Javier Mascherano, have been recalled to the Argentina squad for upcoming World Cup qualifiers.
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