The return leg is at the San Siro next Thursday. Looks to be all over bar the shouting with Inter needing a 4-0 victory to progress.
Final whistle sounds! 3-0 to Spurs. Inter just happy to get out of town.
We are into three minutes of time added on.
Another offside flag is raised against Inter as Pereira ventures narrowly offside for the visiting team.
Bale showing off some of his skills with the inside and outside of his boots. A real classy performer for Spurs this evening.
Guarin fires a shot at goal. Blocked by Gallas and the ball deflects into the arms of Friedel.
Walker on the dash again for Spurs. Gets the ball across goal, but straight into the arms of Handanovic.
Parker breaks up another Inter attack, but Holtby can't control the ball. Spurs losing some of their intensity late on.
Parker has been a real willing runner for Spurs through the centre. Cassano slides a cross into the home area, but Guarin is just off the pace.
Pereira does enough to hold up the run of Parker before Zanetti wins the ball from Holtby.
Kyle Naughton is introduced to take over from Lennon. And on we go with Spurs leading 3-0 and in complete control.
Lennon on the deck needing some treatment. This might be the end of the road for him.
Holtby with the shot from distance. Inter do just enough to take the sting out of the shot. All the Spurs players keen to get in on the act now.
Palacio is flagged for offside as another Inter attack bites the dust. Story of the night really.
Bale juggles the ball into the heart of the Inter box, but just can't bring the ball down in time. Goalkick to the visiting side.
Pereira catches Lennon with a late tackle and he is booked for that effort. Another dismal moment for Inter.
Spurs don't want to concede here as there is a huge difference between 3-0 and 3-1 ahead of of next week's return leg.
Golden chance for Palacio racing through the middle from Cambiasso's free-kick. Fine stop by Friedel in the Spurs goal. Had to be alert to make that stop.
Those Inter fans looking fairly grim in the visiting end. Little wonder. Has not really been worth the trip so far.
A yellow card is going to be shown to Guarin for a basic dive with Gallas leaving a leg hanging out.
Palacio throws the ball deep to the back post, but it is more in hope with Cambiasso never going to connect with that cross.
Sigurdsson departs the scene to be replaced by Lewis Holtby for the home side.
Parker runs through the middle of the Inter midfield. Picks out Lennon, but he can't come up with the finish as Handanovic spreads himself to make the stop.
Ranocchia wins the ball from Defoe. Had to get that challenge spot on. Lovely ball from Sigurdsson.
Offside flag goes up against Cassano. Nothing really going right for Inter here.
Jonathan arrives to take over from the disappointing Alvarez.
Defoe on the charge for Spurs. Great move on the break, but Zanetti does enough to win the ball. Defoe could easily have played in a team-mate there.
Change comes for Spurs as Dembele departs the scene to be replaced by Jake Livermore for Spurs.
Defoe breaks clear. Turns and shoots from Parker's pass. Handanovic does just enough to scramble that effort wide of goal.
Chivu has obvious problems with Bale. Cambiasso empties a pass straight out of play. Poor, poor stuff from the Italians.
Bale runs straight at that Inter defence before thumping a shot wide of goal. Inter living in fear every time Bale goes at them.
Friedel thumps the long ball down the park from deep. Luis Figo cutting a concerned figure among the Inter technical staff.
Bale drives a free-kick into the heart of the Inter box, but this time Handanovic comes to collect with some ease.
The Spurs chairman Daniel Levy looking very relaxed with life in the stands. Little wonder watching this dismantling.
Change coming for Inter as Guarin arrives to take over from Kovacic.
Walker dashes back to win the ball from Palacio. Spurs oozing confidence against an Inter side who are being put through the mill here.
Spurs have only lost one of their last 78 European games after scoring 2+ goals, but that defeat came verus Inter in 2010 - 3-4.
Inter an utter shambles at the back. Zonal marking, but they were marking fresh air. Inter now surely need an away goal to have any chance.
GOAL! Vertonghen rises above Chivu to head home from five yards. Bale with the corner and that is a 3-0 lead for Spurs.
Ranocchia cuts off the cross from Defoe and that will be a corner to Spurs. Their latest corner.
Pereira gets away from Lennon pressing forward, but he can't hit the target as the ball flies wide of goal. Decent attacking move from Inter.
Rodrigo Palacio has replaced Juan to partner Cassano up front. Not seem much of Inter going forward in this second half.
Bale throws the free-kick deep to the back post. Pereira can't mark Vertonghen, but he can't connect with the loose ball. Glorious chance for Spurs to move 3-0 clear.
Bale deemed to have brought down Pereira and Spurs have a free-kick out wide.
Zanetti with a clearance from inside his own box before a flag goes up against Walker for offside. Spurs starting off like they did in the first period.
We are off and running in the second half of this match.
There goes the whistle for the break! A 2-0 lead for Spurs which is richly deserved. Inter must steel themselves to stay alive in the tie ahead of next week's return leg.
We are into one minute of time added on.
The home fans getting right behind their side and that man Bale as they calm matters down again.
Spurs with almost 60 percent of possession as we approach half-time. Apart from the past five minutes or so, has been a dominant effort by the home side.
Juan Jesus is being spoken to by the referee for throwing the ball away. Fortunate to avoid a booking for a spot of frustration.
Walker bundles the ball into the stands, but this is better from Inter after such a rocky spell in the first half.
Another hit by Alvarez from distance, but this time the shot is deflected wide of goal for a corner. Vertonghen rises to head clear.
Alvarez misses a glorious chance to net for Inter. Cassano with the deflected through ball. Only Friedel to beat, but he drives the ball wide of goal. Bad miss.
Bale goes deep to the back post. Vertonghen with the header back across goal that is held by Handanovic.
Tesing ball into the middle by Assou-Ekotto, but Juan knocks it behind for a corner-kick to Spurs.
Cassano tries to get another move going, but Cambiasso is hustled out of it by a plethora of white shirts.
Lennon fails to control the ball out wide, but Spurs are quickly back in the hunt as Sigurdsson drives a shot at goal that is held by Handanovic.
Sigurdsson is providing so much for Spurs and Bale as Chivu heads out the latest Bale cross.
Bale heads wide of goal from another Sigurdsson cross. That Inter central defence giving real cause for concern.
Sigurdsson and Pereira suffer a clash of shins. Bit of discomfort, but nothing of great concern. Friedel hammers the ball long from his box.
Parker giving Cambiasso the slip before picking out Gallas. Spurs winning all the 50-50 balls so far in this contest. A real high tempo approach.
Of the sides that started the Europa League group stage, only two remain unbeaten after eight matches – Lazio and Tottenham, who qualified together from Group J.
Cassano goes deep with the corner, but Ranocchia nods wide of the goal for a Spurs goalkick.
Cassano tries to lift the ball into Alvarez, but Spurs have enough bodies back before Pereira earns his side a corner.
Andrea Stramaccioni trying to encourage his side to calm their jets. This tie could fall away from Inter before half-time unless the Italians are careful. All very rash.
Bale was booked against NK Maribor and Panithinaikos. He misses the second leg. But may not be missed as Handanovic nudges a Vertonghen header over his bar.
Parker alert to snuff out a run of Cambiasso. Easy enough for Friedel to pick up in the Tottenham goal. Spurs then come again.
Chivu making a timely tackle on Bale as he set off on another of those mazy runs from out wide. Inter being forced back.
Mateo Kovačić brings down Parker with a late challenge. Inter struggling to get any time on the ball.
Defoe just failing to pick out Lennon before Dembele puts the block on Alvarez at the other end. Lots of pace in this match.
Juan Jesus doing well to halt the run of Walker before Cassano goes to ground under a challenge from Gallas.
Spurs playing some gorgeous football so far. Inter can't get near the ball. Another goal would surely kill this tie stone dead before next week.
GOAL! Sigurdsson tucks the ball into the net after Handanovic had stopped Defoe's shot from Lennon's cutback. A 2-0 lead for Spurs. Long way back here for Inter.
Bale is suspended for the return leg of this match at the San Siro next Thursday. Here come Spurs looking for a second goal.
Alvarez this time picks out Kovacic, but he leans back and lifts his effort over the bar from 18 yards out. Better from Inter.
No Italian side has ever won at White Hart Lane in Europe with two defeats and two draws for the visitors. Doesn't look too bright for them so far, but here comes Alvarez.
Cassano plays the ball to Cambiasso, whose run over the ball fails to find Alvarez. Easy clearance for Spurs to make there.
Parker and Bale play a neat one-two before Bale is booked for apparently taking a dive. Gargano never made contact in the box. It was a clear dive.
Bale thumps the shot at goal from distance, but straight into the paws of Handanovic that time. Solid stop.
Bale tries to pick out Parker, but that is fine sliding challenge by Chivu on the edge of his own area.
Defoe seemed to be nudged to the deck by Juan out wide, but the linesman decides to award a goalkick to the visitors.
Gargano concedes a free-kick for a foul on Dembélé. Spurs starting extremely well and playing with some real swagger here.
Gareth Bale has now bagged 11 goals in his last nine games for club and country. Astonishing stuff from the Welsh wonder.
Another brilliant run and pass from Bale. Picks out Defoe, whose powerful shot is blocked by Handanovic in the visiting goal.
Superb stuff from Bale. Not sure what Cambiasso was doing in trying to mark Bale. Never got near the ball. Inter must try to settle themselves here.
GOAL! Bale rises to head into the corner of the net from Sigurdsson's cross. Brilliant finish by Bale and Spurs have the lead.
Inter have won five of their six away games in Europe this season, scoring three goals in four of those victories. They know how to get the job done away from home.
Alvarez thumps a shot miles over from distance in the home half. Both teams looking well up for this contest.
Bale swipes a leg at a ball after some neat playing involving Walker and Lennon. Walker with the pass, but Bale fails to connect.
Spurs in white and Inter are all in red. Lovely night for football and that pitch is like a bowling green.
A big night then for Spurs. A quick huddle and we are almost ready to go here.
Andrea Stramaccioni on the challenge facing Inter to mark Bale: "Gareth Bale is becoming one of the most complete players in Europe, because he is proving always decisive as well as having great quality. There is respect for Bale, just as for Aaron Lennon, Jermain Defoe and the other great Tottenham players. However, we too have champions and I am certain Spurs respect us. We have no fear."
Andre Villas-Boas: "Playing Inter is an emotional experience. I spent 18 months there, was made welcome and still speak to people there two or three times a week. I was scouting for Jose (Mourinho) and we had a conversation as I wanted to be more involved with first team training. We decided our contract at Inter would be the last one together and I went to Academica."
Antonio Cassano has been recalled to the Inter squad after being punished for a row with manager Andrea Stramaccioni by being dropped for the weekend's victory over Catania. He starts the match, but Inter are without key names such as Walter Samuel, Diego Milito and Andrea Ranocchia due to injury.
Tottenham striker Emmanuel Adebayor is missing after suffering a knee injury during Sunday's north London derby win over Arsenal. Mousa Dembele, like Adebayor, came off during that match but trained on Wednesday morning and has been passed fit to start. Younes Kaboul, Sandro and Tom Huddlestone (all knee) are unavailable while Clint Dempsey (calf) is out and Hugo Lloris makes way for Brad Friedel in goal.
Teams: Tottenham: Friedel, Walker, Vertonghen, Gallas, Assou-Ekotto, Dembele, Parker, Lennon, Sigurdsson, Bale, Defoe..subs: Lloris, Caulker, Naughton, Dawson, Livermore, Carroll, Holtby////Inter Milan: Handanovic, Zanetti, Ranocchia, Chivu, Juan Jesus, Gargano, Cambiasso, Alvarez, Kovacic, Pereira, Cassano..subs: Belec, Benassi, Pasa, Mbaye, Jonathan, Guarin, Palacio
Good evening and welcome to LIVE coverage of Inter Milan against Tottenham from the Europa League last 16 first leg at White Hart Lane.