Ajax and Benfica, two of European football's biggest names, qualified for the last 16 of the Europa League after the Dutch beat Anderlecht 2-0 and the Portuguese won by the same score at Stuttgart
PSV Eindhoven beat Lille 3-1 to progress from a meeting of Dutch and French league leaders while Russian pair Zenit St Petersburg and Spartak Moscow overcame Swiss opposition in frigid conditions.
Germany captain Michael Ballack was among the scorers as Bayer Leverkusen beat Metalist Kharkiv 2-0 to complete a 6-0 aggregate victory over the Ukrainians.
, who beat Besiktas 4-0 with Andriy Shevchenko among the scorers for an emphatic 8-1 aggregate scoreline.
Braga, who beat Lech Poznan 2-0 for a 2-1 aggregate win, in the next round.
Serb Miralem Sulejmani scored two early goals as four-times European champions Ajax completed a 5-0 win over their Belgian opponents and former UEFA Cup winners Anderlecht.
Benfica's Eduardo Salvio and Oscar Cardozo, two members of their South American contingent, completed a 4-1 aggregate win for former European champions Benfica over Stuttgart.
The Portuguese will next play Paris St Germain after the French side went through on away goals against BATE Borisov.
Pierre-Alain Frau gave Lille a half-time lead at PSV but Balasz Dzsudzsak, Jeremain Lens and Marcelo replied for the Dutch in an 18-minute spell as they won 5-3 on aggregate.
Russian champions and 2008 UEFA Cup winners Zenit St Petersburg came back from the brink of elimination to beat Young Boys Berne 3-1 and 4-3 on aggregate.
Ammar Jemal gave the Swiss the lead in a game which kicked off in a temperature of minus 9 Celsius, slightly warmer than predicted earlier this week.
Danko Lazovic and Sergei Semak replied for Zenit either side of halftime and Roman Shirokov scored the winner.
Spartak Moscow drew 1-1 at home to FC Basel in even colder conditions - around minus 15 - to go through 4-3 on aggregate and earn a tie against Ajax.
With CSKA Moscow qualifying on Wednesday for a last 16 tie with Porto, compatriots Rubin Kazan, who squandered a 2-0 lead at Twente Enschede to draw 2-2 and lose 4-2 on aggregate, were the only Russian side to go out.
Twente will play Zenit in the next round.