Valencia beat nine-man Basel 5-0 after extra-time to overhaul a three-goal deficit and reach the semi-finals of the Europa League.
Sevilla were drawn against Valencia in the semi-finals of the Europa League, with Portuguese side Benfica taking on Juventus.
Andrea Pirlo scored a trademark free-kick as Juventus moved into the last four of the Europa League with a 2-1 win.
Round-up: Ten-man Sevilla tormented a fragile Porto side to reach the Europa League semi-finals with a 4-2 aggregate win.
Sevilla know they are up against it in the second leg of their Europa League clash with Porto.
Juventus's Leonardo Bonucci scored in the 85th minute to snatch a 1-0 win over Lyon in their Europa League quarter-final.
Round-up: Porto secured a 1-0 lead over Sevilla, earned by a fine header from Eliaquim Mangala in the 31st minute.
FC Basel have been ordered to play their next European home game behind closed doors.
Favourites Juventus were handed a difficult tie against Olympique Lyon in the Europa League quarter-finals following Friday's draw at UEFA headquarters.
Two away goals scored against the run of play saw Napoli crash out of the Europa League to Porto.
Benfica survived a late scare to book their spot in the last eight as a 2-2 draw with Spurs saw them prevail 5-3 on aggregate.
Round-up: Andrea Pirlo kept Juventus on course for a home final after a superb free-kick settled the last 16 battle with Fiorentina.
Salzburg's match at home to FC Basel was interrupted for 12 minutes when fans of the visiting Swiss side threw objects on to the pitch.
Injury-hit Tottenham have had to bring in seven players who have yet to play for the first team for the match against Benfica.
Tim Sherwood had no problem with his players' desire in their defeat to Benfica, but was unhappy with "classless" Jorge Jesus.
Tottenham Hotspur suffered a 3-1 defeat at White Hart Lane at the hands of Benfica, with captain Luisao bagging a brace for the visitors.