Spanish striker Xisco has been added to the casualty list with a slight groin strain which could also keep him out of Saturday's Barclays Premier League trip to Wolves, while midfielder Danny Guthrie is yet to recover from his knee problem.
Accrington manager John Coleman is waiting on the fitness of Craig Lindfield ahead of the visit of Newcastle.
The striker has been suffering from a recurring knee injury and missed Saturday's victory over Macclesfield.
The 21-year-old failed a fitness test prior to the clash but Stanley will take another look ahead of the tie with the Magpies.
Rory Boulding is likely to continue in attack after recovering from an Achilles problem sustained on the opening day of the season.
Leam Richardson will be pressing for a start after penning new terms at the club following a long injury lay-off.
Coleman's team opened up their scoring account in the league in the defeat of the Silkmen, with Sean McConville bagging a hat-trick in a 3-0 triumph at the Crown Ground.