Johan Bruyneel, directeur sportif of Schleck's team, RadioShack-Nissan, said in his blog that the Luxembourger would instead be making his return from injury at the USA Pro cycling Challenge in Colorado, which starts two days after the final grand tour of the season gets underway in Spain.
"I'm happy to report that Andy Schleck is set to resume racing soon," Bruyneel wrote. "We've established a schedule for the remainder of the season where he should be in a good position to attain results - USA Pro Cycling Challenge, Canadian races, followed by Worlds and the two Chinese races.
"As of today, our Vuelta team will be led by Maxime Monfort and Tiago Machado. Final selection of the roster has yet to be decided, but I can declare that we will show up in Pamplona with a very competitive squad."
Schleck has been out of action since sustaining a pelvic injury in a crash during the time trial at the Criterium de Dauphine back in early June.
That blow ruled him out of the Tour de France and the London Olympics.