Durant, the Most Valuable Player of the 2010 world championship tournament in Turkey for the gold-medal winning Americans, picked up where he left off on the international stage with a game-high 24 points and 10 rebounds.
Overmatched and weary after missing out on the final Olympic berth with a loss to Nigeria in the qualifying tournament, the Dominicans were harassed into mistakes by the Americans.
The Olympic champions used their quickness to force turnovers, converting their fast break opportunities into soaring dunks, while Durant and Andre Iguodala showed off their sharpshooters' touch.
Durant hit 9-of-12 from the floor including 6-of-8 from three-point range, while Philadelphia 76ers swingman Iguodala shot 4-of-6 from beyond the arc and scored 18 points.
Three-time NBA scoring champion Durant knocked down his first five three-pointers and had 21 points as the Americans surged to a 50-27 lead by halftime.
Anthony Davis, the top pick in the NBA Draft by the New Orleans Hornets, filled in for injured Los Angeles Clippers forward Blake Griffin, who left the Las Vegas training camp on Thursday for a medical examination after complaining of soreness in his left knee.